CANX binds Glu1Man9GlcNAc2-CDH1

Stable Identifier
R-HSA-9932988
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
ReviewStatus
3/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CANX binds Glu1Man9GlcNAc2-CDH1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After Glucosidase II complex-mediated removal of the second glucose residue, the Glu1Man9GlcNAc2-proteoglycans enter the so-called calnexin/calreticulin cycle, binding to chaperones CANX (calnexin) (membrane-bound glycoproteins) or CALR (calreticulin) (soluble glycoproteins), which ensure proper folding of nascent glycoproteins (reviewed in Helenius and Aebi 2004). CDH1 binds to CANX, and the binding is increased for recombinant mutant CDH1 proteins that are unable to be properly glycosylated and are, thus, likely misfolded (Zhou et al. 2008). CALR positively affects presentation of CDH1 on the plasma membrane, with CALR knockdown leading to decreased plasma membrane levels of CDH1 and accumulation of CDH1 in cis Golgi (Iwahashi et al. 2019). No binding between CDH1 and calreticulin has been tested (Iwahashi et al. 2019) and the effect of CALR on CDH1 plasma membrane presentation may be indirect.
Literature References
PubMed ID Title Journal Year
18491227 Unglycosylation at Asn-633 made extracellular domain of E-cadherin folded incorrectly and arrested in endoplasmic reticulum, then sequentially degraded by ERAD

Zhou, F, Su, J, Fu, L, Yang, Y, Zhang, L, Wang, L, Zhao, H, Zhang, D, Li, Z, Zha, X

Glycoconj J 2008
Participants
Input
Output
Participates
as an event of
Orthologous Events
CANX binds Glu1Man9GlcNAc2-CDH1 (Bos taurus)
CANX binds Glu1Man9GlcNAc2-CDH1 (Canis familiaris)
CANX binds Glu1Man9GlcNAc2-CDH1 (Danio rerio)
CANX binds Glu1Man9GlcNAc2-CDH1 (Gallus gallus)
CANX binds Glu1Man9GlcNAc2-CDH1 (Mus musculus)
CANX binds Glu1Man9GlcNAc2-CDH1 (Rattus norvegicus)
CANX binds Glu1Man9GlcNAc2-CDH1 (Sus scrofa)
CANX binds Glu1Man9GlcNAc2-CDH1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2024-12-21)
Created
Orlic-Milacic, M  (2024-12-21)
Cite Us!