Reactome | TMEM258 [endoplasmic reticulum membrane]

TMEM258 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9932192

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

fullName evidence="9"Transmembrane protein 258, TM258_HUMAN

Locations in the PathwayBrowser

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 posttranslational processing and trafficking to plasma membrane (Homo sapiens)
        
        CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum (Homo sapiens)
        
        OST-A [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST Subcomplex I [endoplasmic reticulum membrane] (Homo sapiens)
        
        TMEM258 [endoplasmic reticulum membrane] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Regulation of PD-L1(CD274) expression (Homo sapiens)
        
        Regulation of PD-L1(CD274) Post-translational modification (Homo sapiens)
        
        PD-L1(CD274) glycosylation and translocation to plasma membrane (Homo sapiens)
        
        CD274 N-linked glycosylation in ER (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST Subcomplex I [endoplasmic reticulum membrane] (Homo sapiens)
        
        TMEM258 [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-B [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST Subcomplex I [endoplasmic reticulum membrane] (Homo sapiens)
        
        TMEM258 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61165 TMEM258

Gene Names

TMEM258, C11orf10, HSPC005

Chain

chain:1-79

Reference Genes

BioGPS Gene:746 TMEM258

COSMIC (genes):TMEM258 TMEM258

CTD Gene:746 TMEM258

dbSNP Gene:746 TMEM258

ENSEMBL:ENSG00000134825 TMEM258

HGNC:1164 TMEM258

KEGG:hsa:746 TMEM258

Monarch:746 TMEM258

NCBI Gene:746 TMEM258

OMIM:617615 TMEM258

UCSC:P61165 TMEM258

Reference Transcript

RefSeq:NM_014206.4 TMEM258

Other Identifiers

11716013_s_at

11758739_at

16739117

218213_PM_s_at

218213_s_at

3375515

3375516

3375517

3375519

3375520

3375521

3375522

3375523

3375524

3375525

3375526

3375527

3375528

3375530

3375531

3375532

46689_at

746

7948606

A_23_P47527

GE58572

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0006486

GO:0006487

GO:0006954

GO:0008250

GO:0016020

GO:0034976

GO:0062062

GO:0160226

GO:0160227

GO:1904019

HMNXSV003034125

HMNXSV003043992

ILMN_1786759

PH_hs_0025638

TC11001857.hg

g7656933_3p_s_at

p2317

Participates

as a component of

OST Subcomplex I [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

Tmem258 [endoplasmic reticulum membrane] (Mus musculus)

Tmem258b [endoplasmic reticulum membrane] (Rattus norvegicus)

tmem258 [endoplasmic reticulum membrane] (Danio rerio)

TMEM258 [endoplasmic reticulum membrane] (Bos taurus)

TMEM258 [endoplasmic reticulum membrane] (Canis familiaris)

TMEM258 [endoplasmic reticulum membrane] (Gallus gallus)

TMEM258 [endoplasmic reticulum membrane] (Sus scrofa)

Ghost homologue of TMEM258 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Homologues of TMEM258 [endoplasmic reticulum membrane] (Canis familiaris)

LOC119868947 [endoplasmic reticulum membrane] (Canis familiaris)

Cross References

RefSeq

NP_055021.1

ENSEMBL

ENST00000257262, ENST00000537328, ENSP00000443216, ENSG00000134825, ENSP00000257262

OpenTargets

ENSG00000134825

GeneCards

TMEM258

HPA

ENSG00000134825-TMEM258

PRO

P61165

Pharos - Targets

P61165

GlyGen

P61165

PDB

8PN9, 8B6L, 6S7O, 6S7T

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC4 E	9	Ub-3xPalmC-E [virion membrane] (R-COV-9698416) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698422) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698420) Ub-3xPalmC-E [Golgi membrane] (R-COV-9694687) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9694465) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694423) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694305) nascent E [endoplasmic reticulum lumen] (R-COV-9694312) N-glycan E [endoplasmic reticulum lumen] (R-COV-9694754)	0.556	3