Reactome | OST4 [endoplasmic reticulum membrane]

OST4 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9932191

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

fullName evidence="5"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4, OST4_HUMAN

Locations in the PathwayBrowser

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 posttranslational processing and trafficking to plasma membrane (Homo sapiens)
        
        CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum (Homo sapiens)
        
        OST-A [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST4 [endoplasmic reticulum membrane] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Regulation of PD-L1(CD274) expression (Homo sapiens)
        
        Regulation of PD-L1(CD274) Post-translational modification (Homo sapiens)
        
        PD-L1(CD274) glycosylation and translocation to plasma membrane (Homo sapiens)
        
        CD274 N-linked glycosylation in ER (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST4 [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-B [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-B Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST4 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P0C6T2 OST4

Gene Names

OST4

Chain

chain:1-37

Reference Genes

BioGPS Gene:100128731 OST4

COSMIC - genes:OST4 OST4

CTD Gene:100128731 OST4

dbSNP Gene:100128731 OST4

ENSEMBL:ENSG00000228474 OST4

HGNC:32483 OST4

KEGG:hsa:100128731 OST4

Monarch:100128731 OST4

NCBI Gene:100128731 OST4

OMIM:618932 OST4

UCSC:P0C6T2 OST4

Reference Transcript

RefSeq:NM_001134693.2 OST4

Other Identifiers

100128731

11717193_a_at

11757651_x_at

16895622

224637_PM_at

224637_at

2545463

2545464

2545465

2545466

2545467

2545468

48835_s_at

89911_s_at

A_32_P57854

GE85879

GO:0005515

GO:0005783

GO:0005789

GO:0006486

GO:0006487

GO:0008250

GO:0016020

GO:0018279

GO:0160226

GO:0160227

HMNXSV003022071

Hs.16420.1.S1_3p_s_at

ILMN_1739335

PH_hs_0036101

TC02001673.hg

Participates

as a component of

Inferred To

ost4 [endoplasmic reticulum membrane] (Danio rerio)

OST4 [endoplasmic reticulum membrane] (Bos taurus)

Ost4 [endoplasmic reticulum membrane] (Mus musculus)

Ost4 [endoplasmic reticulum membrane] (Rattus norvegicus)

Ghost homologue of OST4 [endoplasmic reticulum membrane] (Canis familiaris)

Ghost homologue of OST4 [endoplasmic reticulum membrane] (Gallus gallus)

Ghost homologue of OST4 [endoplasmic reticulum membrane] (Sus scrofa)

Ghost homologue of OST4 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001128165.1

ENSEMBL

ENST00000429985, ENST00000447619, ENSP00000455716, ENSG00000228474, ENSP00000457935, ENST00000456793, ENSP00000454411

OpenTargets

ENSG00000228474

GeneCards

OST4

HPA

ENSG00000228474-OST4

PRO

P0C6T2

Pharos - Targets

P0C6T2

PDB

6S7T, 6S7O, 8PN9, 8B6L, 2LAT

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:A6NI15 MSGN1	1	MSGN1 [nucleoplasm] (R-HSA-9793376)	0.556	3

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