p-S195-CD274 binds ERAD complex

Stable Identifier
R-HSA-9931313
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Upon phosphorylation by AMPK, PD-L1 (CD274) is abnormally glycosylated due to abnormal mannose trimming and is tagged for ER-associated protein degradation (ERAD- mediated clearance. AMPK phosphorylated PD-L1 binds to the ERAD complex and is tagged for ubiquitination/degradation (Cha et al., 2018, Dai et al, 2021).
Literature References
PubMed ID Title Journal Year
30118680 Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

Cha, JH, Yang, WH, Xia, W, Wei, Y, Chan, LC, Lim, SO, Li, CW, Kim, T, Chang, SS, Lee, HH, Hsu, JL, Wang, HL, Kuo, CW, Chang, WC, Hadad, S, Purdie, CA, McCoy, AM, Cai, S, Tu, Y, Litton, JK, Mittendorf, EA, Moulder, SL, Symmans, WF, Thompson, AM, Piwnica-Worms, H, Chen, CH, Khoo, KH, Hung, MC

Mol Cell 2018
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