Reactome | IL6-activated JAK1 phosphorylates CD274

IL6-activated JAK1 phosphorylates CD274

Stable Identifier

R-HSA-9931290

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Regulation of PD-L1(CD274) expression (Homo sapiens)
        
        Regulation of PD-L1(CD274) Post-translational modification (Homo sapiens)
        
        PD-L1(CD274) glycosylation and translocation to plasma membrane (Homo sapiens)
        
        IL6-activated JAK1 phosphorylates CD274 (Homo sapiens)

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PD-L1 (CD274) is phosphorylated by IL6-activated JAK1 at Tyr112 (Y112), which helps in the N-glycosylation of PD-L1 in the endoplasmic reticulum (ER) lumen by facilitating the recruitment of ER-associated N-glycosyltransferase STT3A (part of the OST-A complex) to catalyse PD-L1 glycosylation (Chan et al., 2019). This process aids in stabilizing the PD-L1 protein.

Literature References

PubMed ID	Title	Journal	Year
31305264	IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion Chan, LC, Li, CW, Xia, W, Hsu, JM, Lee, HH, Cha, JH, Wang, HL, Yang, WH, Yen, EY, Chang, WC, Zha, Z, Lim, SO, Lai, YJ, Liu, C, Liu, J, Dong, Q, Yang, Y, Sun, L, Wei, Y, Nie, L, Hsu, JL, Li, H, Ye, Q, Hassan, MM, Amin, HM, Kaseb, AO, Lin, X, Wang, SC, Hung, MC	J Clin Invest	2019