Reactome | Transport of N-glycosylated CD274 to Golgi

Transport of N-glycosylated CD274 to Golgi

Stable Identifier

R-HSA-9931262

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, Golgi membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Regulation of PD-L1(CD274) expression (Homo sapiens)
        
        Regulation of PD-L1(CD274) Post-translational modification (Homo sapiens)
        
        PD-L1(CD274) glycosylation and translocation to plasma membrane (Homo sapiens)
        
        Transport of N-glycosylated CD274 to Golgi (Homo sapiens)

General

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Transport of N-glycosylated CD274 to Golgi

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PD-L1 (CD274), once glycosylated in the ER lumen, gets translocated to the Golgi complex for further glycosylation and K62 ubiquitination (Cha et al., 2018, Li et al., 2016). This step is important for the further maturation of the PD-L1 protein.

Literature References

PubMed ID	Title	Journal	Year
30118680	Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 Cha, JH, Yang, WH, Xia, W, Wei, Y, Chan, LC, Lim, SO, Li, CW, Kim, T, Chang, SS, Lee, HH, Hsu, JL, Wang, HL, Kuo, CW, Chang, WC, Hadad, S, Purdie, CA, McCoy, AM, Cai, S, Tu, Y, Litton, JK, Mittendorf, EA, Moulder, SL, Symmans, WF, Thompson, AM, Piwnica-Worms, H, Chen, CH, Khoo, KH, Hung, MC	Mol Cell	2018