Reactome | CCNA:CDK1 complex translocates to the cytosol

CCNA:CDK1 complex translocates to the cytosol

Stable Identifier

R-HSA-9929533

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

CCNA:CDK1 complex translocates to the cytosol

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Endogenous CCNA2 is exclusively nuclear in S phase but shows both nuclear and cytosolic localization from early G2 (Gheghiani et al. 2017, Silva Cascales et al. 2021). WEE1 activity does not affect the intracellular distribution of CCNA2 (Gheghiani et al. 2017, Silva Cascales et al. 2021). Inhibition of CDK1 and CDK2 catalytic activity does not compromise cytoplasmic accumulation of CCNA2 once initiated (Silva Cascales et al. 2021). CDK1 appears to facilitate the translocation of CCNA2 to the cytosol, while CDK2 has no effect, although both CDK1 and CDK2 co-immunoprecipitate with cytosolic CCNA2 (Silva Cascales et al. 2021). Cytosolic CCNA2 promotes PLK1 activation (Silva Cascales et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
28591578	PLK1 Activation in Late G2 Sets Up Commitment to Mitosis Gheghiani, L, Loew, D, Lombard, B, Mansfeld, J, Gavet, O	Cell Rep	2017
33402344	Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1 Silva Cascales, H, Burdova, K, Middleton, A, Kuzin, V, Müllers, E, Stoy, H, Baranello, L, Macurek, L, Lindqvist, A	Life Sci Alliance	2021