Reactome | CD274 ubiquitination by SPOP:CUL3:RBX1 complex

CD274 ubiquitination by SPOP:CUL3:RBX1 complex

Stable Identifier

R-HSA-9929490

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Regulation of PD-L1(CD274) expression (Homo sapiens)
        
        Regulation of PD-L1(CD274) Post-translational modification (Homo sapiens)
        
        SPOP-mediated proteasomal degradation of PD-L1(CD274) (Homo sapiens)
        
        CD274 ubiquitination by SPOP:CUL3:RBX1 complex (Homo sapiens)

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CD274 ubiquitination by SPOP:CUL3:RBX1 complex

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SPOP:CUL3:RBX1 E3-ubiquitin ligase complex polyubiquitinates PD-L1 and induces its proteasomal degradation (Zhang et al., 2018, Dong et al., 2022).

Literature References

PubMed ID	Title	Journal	Year
36198437	CUL3/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein Dong, M, Qian, M, Ruan, Z	J Immunother Cancer	2022
29160310	Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance Zhang, J, Bu, X, Wang, H, Zhu, Y, Geng, Y, Nihira, NT, Tan, Y, Ci, Y, Wu, F, Dai, X, Guo, J, Huang, YH, Fan, C, Ren, S, Sun, Y, Freeman, GJ, Sicinski, P, Wei, W	Nature	2018