Reactome | p-S6-SPOP binds YWHAG

p-S6-SPOP binds YWHAG

Stable Identifier

R-HSA-9929487

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Regulation of PD-L1(CD274) expression (Homo sapiens)
        
        Regulation of PD-L1(CD274) Post-translational modification (Homo sapiens)
        
        SPOP-mediated proteasomal degradation of PD-L1(CD274) (Homo sapiens)
        
        p-S6-SPOP binds YWHAG (Homo sapiens)

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14-3-3 protein gamma (YWHAG) binds with the SPOP phosphorylated by the Cyclin D1:CDK4 complex and induces its sequestration, thus stabilizing PD-L1 (CD274) by inhibiting its SPOP:CUL3:RBX1-induced ubiquitination and degradation (Zhang et al., 2018)

Literature References

PubMed ID	Title	Journal	Year
29160310	Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance Zhang, J, Bu, X, Wang, H, Zhu, Y, Geng, Y, Nihira, NT, Tan, Y, Ci, Y, Wu, F, Dai, X, Guo, J, Huang, YH, Fan, C, Ren, S, Sun, Y, Freeman, GJ, Sicinski, P, Wei, W	Nature	2018