Reactome | SDS dimers:PXLP convert L-Ser to PYR and NH4+

SDS dimers:PXLP convert L-Ser to PYR and NH4+

Stable Identifier

R-HSA-9929460

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

L-serine => NH4(+) + pyruvate

ReviewStatus

5/5

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SDS dimers:PXLP convert L-Ser to PYR and NH4+

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Both SDS (L-serine dehydratase/L-threonine deaminase) and SDSL (Serine dehydratase-like), covalently conjugated with PXLP, form dimers that catalyze the reaction of L-serine (L-Ser) to form pyruvate (PYR) and ammonium (NH4+). These reactions occur in the cytosol (Ogawa et al. 2006; Yamada et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18342636	A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies Yamada, T, Komoto, J, Kasuya, T, Takata, Y, Ogawa, H, Mori, H, Takusagawa, F	Biochim. Biophys. Acta	2008
16580895	Enzymatic and biochemical properties of a novel human serine dehydratase isoform Ogawa, H, Gomi, T, Nishizawa, M, Hayakawa, Y, Endo, S, Hayashi, K, Ochiai, H, Takusagawa, F, Pitot, HC, Mori, H, Sakurai, H, Koizumi, K, Saiki, I, Oda, H, Fujishita, T, Miwa, T, Maruyama, M, Kobayashi, M	Biochim Biophys Acta	2006