Deubiquitination of CD274

Stable Identifier
R-HSA-9929353
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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COP9 signalosome 5 (CSN5) poses deubiquitination activity and is known to regulate the SCF (Skp1- cullinF-box)-containing complexes. In the study by Lim et al., 2016, CSN5 induced by TNF-alpha signalling was shown to augment PD-L1 (CD274) stability by deubiquitinating PD-L1.
Literature References
PubMed ID Title Journal Year
33354502 Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5

Liu, Y, Liu, X, Zhang, N, Yin, M, Dong, J, Zeng, Q, Mao, G, Song, D, Liu, L, Deng, H

Acta Pharm Sin B 2020
27866850 Deubiquitination and Stabilization of PD-L1 by CSN5

Lim, SO, Li, CW, Xia, W, Cha, JH, Chan, LC, Wu, Y, Chang, SS, Lin, WC, Hsu, JM, Hsu, YH, Kim, T, Chang, WC, Hsu, JL, Yamaguchi, H, Ding, Q, Wang, Y, Yang, Y, Chen, CH, Sahin, AA, Yu, D, Hortobagyi, GN, Hung, MC

Cancer Cell 2016
Participants
Participates
Catalyst Activity

deubiquitinase activity of CSN5 [cytosol]

Orthologous Events
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