HlyE-loaded OMV leaves cell

Stable Identifier
R-HSA-9926154
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Escherichia coli
Compartment
bacterial outer membrane vesicle, cell outer membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HlyE-loaded OMV leaves cell
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Outer-membrane vesicles (OMVs) containing the pore-forming toxin Hemolysin E (HlyE; aka cytolysin A, ClyA; aka silent haemolysin, SheA) are constantly being discharged from the surface of HlyE-expressing E. coli during bacterial growth. HlyE binds cholesterol, and pore formation by oligomeric assemblies of HlyE in a membrane is stimulated if the membrane contains cholesterol. After the OMVs fuse with host epithelial cells, the pore causes leakage and destruction of these cells, contributing to pathogenicity. Destroyed erythrocytes release hemoglobin which is subsequently cleaved by proteases, making host iron available to the bacterium. The exact mechanism of OMV formation is unclear (Oscarsson et al., 1999; Lai et al., 2000; Wai et al., 2003; Ludwig et al., 2004; reviewed in Roderer & Glockshuber, 2016).
Literature References
PubMed ID Title Journal Year
14532000 Vesicle-mediated export and assembly of pore-forming oligomers of the enterobacterial ClyA cytotoxin

Wai, SN, Lindmark, B, Söderblom, T, Takade, A, Westermark, M, Oscarsson, J, Jass, J, Richter-Dahlfors, A, Mizunoe, Y, Uhlin, BE

Cell 2003
10383763 Molecular analysis of the cytolytic protein ClyA (SheA) from Escherichia coli

Oscarsson, J, Mizunoe, Y, Li, L, Lai, XH, Wieslander, A, Uhlin, BE

Mol Microbiol 1999
10858262 Cytocidal and apoptotic effects of the ClyA protein from Escherichia coli on primary and cultured monocytes and macrophages

Lai, XH, Arencibia, I, Johansson, A, Wai, SN, Oscarsson, J, Kalfas, S, Sundqvist, KG, Mizunoe, Y, Sjöstedt, A, Uhlin, BE

Infect Immun 2000
15292132 Molecular analysis of cytolysin A (ClyA) in pathogenic Escherichia coli strains

Ludwig, A, von Rhein, C, Bauer, S, Hüttinger, C, Goebel, W

J Bacteriol 2004
28630151 Assembly mechanism of the α-pore-forming toxin cytolysin A from Escherichia coli

Roderer, D, Glockshuber, R

Philos Trans R Soc Lond B Biol Sci 2017
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
vesicle budding from membrane (0006900)
Disease
Cross References
Mondo
Authored
Stephan, R  (2024-10-31)
Created
Stephan, R  (2024-10-31)
Cite Us!