Reactome | Translation of NOTCH2NLA mRNA

Translation of NOTCH2NLA mRNA

Stable Identifier

R-HSA-9925730

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

extracellular region, nucleoplasm

ReviewStatus

5/5

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NOTCH2NLA mRNA is translated into NOTCH2NLA protein. The 211 N-terminal amino acids of NOTCH2NLA correspond to the EGF repeats 1 to 6 of NOTCH2 (the EGF repeats 1 and 6 of NOTCH2 are incomplete in NOTCH2NLA) (Duan et al. 2004) and the 24 C-terminal amino acids are unique to NOTCH2NLs (Duan et al. 2004, Fiddes et al. 2018, Suzuki et al. 2018). NOTCH2NLA does not possess regions corresponding to transmembrane and cytoplasmic domains of NOTCH2 (Fiddes et al. 2018).

While the predicted molecular mass of NOTCH2NLA is 26 kDa, its actual mass is closer to 36 kDa, which suggests that the EGF repeats of NOTCH2NLA may undergo glycosylation similar to EGF repeats of NOTCH2 (Duan et al. 2004).

NOTCH2NLA is distributed throughout the cell (Duan et al. 2004) and also secreted (Duan et al. 2004, Fiddes et al. 2018).

Literature References

PubMed ID	Title	Journal	Year
29856954	Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis Fiddes, IT, Lodewijk, GA, Mooring, M, Bosworth, CM, Ewing, AD, Mantalas, GL, Novak, AM, van den Bout, A, Bishara, A, Rosenkrantz, JL, Lorig-Roach, R, Field, AR, Haeussler, M, Russo, L, Bhaduri, A, Nowakowski, TJ, Pollen, AA, Dougherty, ML, Nuttle, X, Addor, MC, Zwolinski, S, Katzman, S, Kriegstein, A, Eichler, EE, Salama, SR, Jacobs, FMJ, Haussler, D	Cell	2018
14673143	A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia Duan, Z, Li, FQ, Wechsler, J, Meade-White, K, Williams, K, Benson, KF, Horwitz, M	Mol Cell Biol	2004
29856955	Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation Suzuki, IK, Gacquer, D, Van Heurck, R, Kumar, D, Wojno, M, Bilheu, A, Herpoel, A, Lambert, N, Cheron, J, Polleux, F, Detours, V, Vanderhaeghen, P	Cell	2018