DENV capped genome (+)-RNA dissociates from RC

Stable Identifier
R-HSA-9923094
Type
Reaction [dissociation]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
cytosol
ReviewStatus
5/5
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DENV capped genome (+)-RNA dissociates from RC
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DENV capped genome (+)-RNA is assumed to dissociate from RC. Part of the free +ssRNA supports translation into polyprotein in the early stage of cell infection, while in later stages newly synthesized genomic +ssRNA serves as a template for further translation or packaging into progeny virions (Fajardo et al., 2020; reviewed in van den Elsen et al., 2021).
Literature References
PubMed ID Title Journal Year
32313955 The flavivirus polymerase NS5 regulates translation of viral genomic RNA

Fajardo, T, Sanford, TJ, Mears, HV, Jasper, A, Storrie, S, Mansur, DS, Sweeney, TR

Nucleic Acids Res 2020
34064113 Molecular Insights into the Flavivirus Replication Complex

van den Elsen, K, Quek, JP, Luo, D

Viruses 2021
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-09-29)
Reviewed
Mansur, DS  (2025-09-18)
Roque Ascenção, F  (2025-10-29)
Roque Ascenção, F  (2026-03-03)
Created
Stephan, R  (2024-09-30)
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