Circularization of (-)-genomic RNA

Stable Identifier
R-HSA-9923074
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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Circularization of (-)-genomic RNA
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The 3' and 5' ends of DENV genomic -ssRNA interact via complementary base pairing to form a circular RNA; this genome circularization, studied in BHK-21 (baby hamster kidney) cells, helps to bring the polymerase-promoter complex near the 3′-transcription initiation site and promotes the correct conformation of the 3′ end of the genome during initiation of replication (Filomatori et al., 2006; reviewed in van den Elsen et al., 2021). We inferred this process from the same process involving +ssRNA.
Literature References
PubMed ID Title Journal Year
34064113 Molecular Insights into the Flavivirus Replication Complex

van den Elsen, K, Quek, JP, Luo, D

Viruses 2021
16882970 A 5' RNA element promotes dengue virus RNA synthesis on a circular genome

Filomatori, CV, Lodeiro, MF, Alvarez, DE, Samsa, MM, Pietrasanta, L, Gamarnik, AV

Genes Dev 2006
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Output
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as an event of
Event Information
Go Biological Process
viral genome circularization (0099009)
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-10-07)
Reviewed
Mansur, DS  (2025-09-18)
Roque Ascenção, F  (2025-10-29)
Roque Ascenção, F  (2026-03-03)
Created
Stephan, R  (2024-09-29)
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