E binds TAL1

Stable Identifier
R-HSA-9921883
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
E binds TAL1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
DENV envelope (E) protein binds to T-cell acute lymphocytic leukemia protein 1 (TAL1). TAL1 normally localizes to the nucleus but in DENV-infected leukemia cells it co-immunoprecipitated with DENV E protein, associating with it at punctate structures in the cytosol. This could potentially affect the availability of free TAL1 and impede the process of megakaryopoiesis. This result was obtained from experiments with the Dengue serotype-2 (DENV-2) P23085 strain (Banerjee et al., 2020).
Literature References
PubMed ID Title Journal Year
33177556 Dengue virus infection impedes megakaryopoiesis in MEG-01 cells where the virus envelope protein interacts with the transcription factor TAL-1

Banerjee, A, Tripathi, A, Duggal, S, Banerjee, A, Vrati, S

Sci Rep 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-09-13)
Reviewed
Roque Ascenção, F  (2025-10-29)
Mansur, DS  (2025-10-29)
Roque Ascenção, F  (2026-03-10)
Created
Stephan, R  (2024-09-14)
Cite Us!