C binds histones

Stable Identifier
R-HSA-9921290
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
nucleoplasm
ReviewStatus
5/5
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C binds histones
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Nuclear DENV C (capsid) protein binds histones H2A, H2B, H3, H4 of liver cells during DENV infection, binding DNA and disrupting nucleosome formation. This result was obtained from experiments with the Dengue serotype-2 (DENV-2) NG-C strain (Colpitts et al., 2011).
Literature References
PubMed ID Title Journal Year
21909430 Dengue virus capsid protein binds core histones and inhibits nucleosome formation in human liver cells

Colpitts, TM, Barthel, S, Wang, P, Fikrig, E

PLoS One 2011
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-09-08)
Reviewed
Roque Ascenção, F  (2025-10-29)
Mansur, DS  (2025-10-29)
Created
Stephan, R  (2024-09-09)
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