NS1 binds MMP9 and TJP1

Stable Identifier
R-HSA-9921202
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
cell junction
ReviewStatus
5/5
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NS1 binds MMP9 and TJP1
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In studies involving human cell lines, DENV NS1 protein was shown to bind directly to matrix metalloproteinase-9 (MMP9) and zona occludens protein 1 (ZO-1). This interaction contributes to the disruption of junctions between human endothelial cells and leads to vascular leakage in mouse models, a potential factor in Dengue hemorrhagic fever. Additionally, NS1 was found to enhance MMP9 expression in human macrophages. These results were obtained from experiments with the Dengue serotype-2 (DENV-2) NGC strain (Pan et al., 2021).
Literature References
PubMed ID Title Journal Year
34310658 DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junction

Pan, P, Li, G, Shen, M, Yu, Z, Ge, W, Lao, Z, Fan, Y, Chen, K, Ding, Z, Wang, W, Wan, P, Shereen, MA, Luo, Z, Chen, X, Zhang, Q, Lin, L, Wu, J

PLoS Pathog 2021
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-09-06)
Reviewed
Roque Ascenção, F  (2025-10-29)
Mansur, DS  (2025-10-29)
Created
Stephan, R  (2024-09-07)
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