NS1 binds Beclin-1

Stable Identifier
R-HSA-9921171
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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NS1 binds Beclin-1
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DENV NS1 protein interacts with Beclin-1 complex, attenuating Beclin-1 cleavage and facilitating autophagy to prevent early cell apoptosis. This result was obtained from experiments with the Dengue serotype-2 (DENV-2) PL046 strain (Lu et al., 2020). The authors suggest that this interaction may occur with the membrane-associated NS1 homodimer within the viral replication complex.
Literature References
PubMed ID Title Journal Year
33352639 Dengue Nonstructural Protein 1 Maintains Autophagy through Retarding Caspase-Mediated Cleavage of Beclin-1

Lu, ZY, Cheng, MH, Yu, CY, Lin, YS, Yeh, TM, Chen, CL, Chen, CC, Wan, SW, Chang, CP

Int J Mol Sci 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-09-05)
Reviewed
Roque Ascenção, F  (2025-10-29)
Mansur, DS  (2025-10-29)
Roque Ascenção, F  (2026-03-03)
Created
Stephan, R  (2024-09-06)
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