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p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm]
Stable Identifier
R-HSA-9920652
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-S90,Ac-K538-ARNTL:p-T451,T461,S440,S441,S446-CLOCK
Locations in the PathwayBrowser
Expand all
Circadian clock (Homo sapiens)
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters (Homo sapiens)
CLOCK acetylates BMAL1 on lysine-538 (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER2 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER3 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:KMT2A:CRY1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:RORA gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex (Homo sapiens)
CSNK1D,E phosphorylates CLOCK in p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL:p-2T,3S-CLOCK:target gene (Homo sapiens)
p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-K538-BMAL1:p-3S,2T-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER2 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER3 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:KMT2A:CRY1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:RORA gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S-CRY:p-S-PER:CSNK1D,E binds p-S90,Ac-K538-BMAL1:p-2T,3S-CLOCK:target gene (Homo sapiens)
p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-K538-BMAL1:p-3S,2T-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER2 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER3 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:KMT2A:CRY1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:RORA gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER2 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER3 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:KMT2A:CRY1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:RORA gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (Homo sapiens)
Participants
components
p-S90,Ac-K538-BMAL1 [nucleoplasm]
(Homo sapiens)
p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm]
(Homo sapiens)
Participates
as a component of
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER3 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:KMT2A:CRY1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER2 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:RORA gene [nucleoplasm] (Homo sapiens)
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