NS3 localizes to the mitochondrial matrix

Stable Identifier
R-HSA-9920575
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
cytosol, mitochondrial matrix
ReviewStatus
5/5
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NS3 localizes to the mitochondrial matrix
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DENV serotype 1 (KX618706) NS3 protein contains a mitochondrial transport signal (MTS) and we inferred the same localization of DENV-2 from these results (Gandikota et al., 2020; Gandhi et al., 2023). DENV-1 NS3 import to the mitochondrial matrix has been demonstrated in human HEK293 cells (Gandhi et al., 2023; Gandikota et al., 2020) and using isolated rat liver mitochondria (Gandikota et al., 2020).
Literature References
PubMed ID Title Journal Year
32581108 Mitochondrial Import of Dengue Virus NS3 Protease and Cleavage of GrpEL1, a Cochaperone of Mitochondrial Hsp70

Gandikota, C, Mohammed, F, Gandhi, L, Maisnam, D, Mattam, U, Rathore, D, Chatterjee, A, Mallick, K, Billoria, A, Prasad, VSV, Sepuri, NBV, Venkataramana, M

J Virol 2020
37534186 Differential localization of dengue virus protease affects cell homeostasis and triggers to thrombocytopenia

Gandhi, L, Maisnam, D, Rathore, D, Chauhan, P, Bonagiri, A, Venkataramana, M

iScience 2023
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Event Information
Go Biological Process
import into the mitochondrion (0170036)
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-09-01)
Reviewed
Mansur, DS  (2025-09-18)
Roque Ascenção, F  (2025-10-29)
Created
Stephan, R  (2024-09-01)
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