NS5 is exported from nucleus

Stable Identifier
R-HSA-9920046
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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NS5 is exported from nucleus
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A portion of nucleus-localized Dengue virus (DENV) NS5 protein is exported to cytosolic regions. This export process, demonstrated in monkey (Vero) and human (HEK293T, 293) cells using DENV-2 strains (New Guinea C and Townsville), requires binding to XPO1 (CRM1) through a nuclear export signal (NES) at residues 327-343 (2818-2834 in the polyprotein) of the NS5 protein (Rawlinson et al., 2009). We display subsequent association with the ER membrane.
Literature References
PubMed ID Title Journal Year
19297323 CRM1-mediated nuclear export of dengue virus RNA polymerase NS5 modulates interleukin-8 induction and virus production

Rawlinson, SM, Pryor, MJ, Wright, PJ, Jans, DA

J Biol Chem 2009
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
nuclear export (0051168)
This event is regulated
Requirements
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-08-19)
Reviewed
Mansur, DS  (2025-09-18)
Roque Ascenção, F  (2025-10-29)
Created
Stephan, R  (2024-08-29)
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