Reactome | NS2B binds to NS345

NS2B binds to NS345

Stable Identifier

R-HSA-9918798

Type

Reaction [binding]

Species

Homo sapiens

Related Species

Dengue virus type 2

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus Genome Translation and Replication (Homo sapiens)
        
        Maturation of DENV proteins (Homo sapiens)
        
        NS2B binds to NS345 (Homo sapiens)

General

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Peptidase activity of the Dengue virus NS345 fragment in presence of NS2B, but not alone, implies the fragment binds the NS2B protein (Cahour et al., 1991; Zhang et al., 1992).

Literature References

PubMed ID	Title	Journal	Year
1531368	Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease Cahour, A, Falgout, B, Lai, CJ	J Virol	1992
1433530	Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 Zhang, L, Mohan, PM, Padmanabhan, R	J Virol	1992

Participants

Input

Output

NS345:NS2B [endoplasmic reticulum membrane] (Dengue virus type 2)

Participates

as an event of

Maturation of DENV proteins (Homo sapiens)

Disease

Name	Identifier	Synonyms
dengue disease	DOID:12205	breakbone fever, Dengue Fever, classic dengue

Cross References

Mondo

0005502

Authored

Stephan, R (2024-08-18)

Reviewed

Mansur, DS (2025-09-18)

Roque Ascenção, F (2025-10-29)

Created

Stephan, R (2024-08-18)

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