Signalase cleaves prM-E-NS1-NS2A

Stable Identifier
R-HSA-9918795
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
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Signalase cleaves prM-E-NS1-NS2A
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The host cell's signal peptidase complex (SPC, SPCS), also known as signalase, cleaves the Dengue virus prM-E-NS1-NS2A fragment, producing pre-E, pre-prM and the NS1-NS2A fragment, which localize to the inner side of the ER membrane (Markoff et al., 1994; reviewed in Roby et al., 2015; see also Zhang et al., 2016). We inferred this result from experiments with the DENV-4 strain.
Literature References
PubMed ID Title Journal Year
27383988 A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

Zhang, R, Miner, JJ, Gorman, MJ, Rausch, K, Ramage, H, White, JP, Zuiani, A, Zhang, P, Fernandez, E, Zhang, Q, Dowd, KA, Pierson, TC, Cherry, S, Diamond, MS

Nature 2016
7941319 Processing of flavivirus structural glycoproteins: stable membrane insertion of premembrane requires the envelope signal peptide

Markoff, L, Chang, A, Falgout, B

Virology 1994
25711963 Post-translational regulation and modifications of flavivirus structural proteins

Roby, JA, Setoh, YX, Hall, RA, Khromykh, AA

J Gen Virol 2015
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of Signal Peptidase [endoplasmic reticulum membrane]

Physical Entity
Signal Peptidase [endoplasmic reticulum membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-08-18)
Reviewed
Mansur, DS  (2025-09-18)
Roque Ascenção, F  (2025-10-29)
Created
Stephan, R  (2024-08-18)
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