Reactome | POLG [mitochondrial matrix]

POLG [mitochondrial matrix]

Stable Identifier

R-HSA-9913624

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

DNA polymerase subunit gamma-1 ecNumber evidence="2 18 39 49"2.7.7.7, DPOG1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P54098 POLG

Gene Names

POLG, MDP1, POLG1, POLGA

Chain

chain:1-1239

Reference Genes

BioGPS Gene:5428 POLG

COSMIC - genes:MDP1 POLG

COSMIC - genes:POLG POLG

CTD Gene:5428 POLG

dbSNP Gene:5428 POLG

ENSEMBL:ENSG00000140521 POLG

HGNC:9179 POLG

KEGG:hsa:5428 POLG

Monarch:5428 POLG

NCBI Gene:5428 POLG

OMIM:174763 POLG

UCSC:P54098 POLG

Reference Transcript

Other Identifiers

1014_at

11718899_at

16813073

203366_3p_at

203366_PM_at

203366_at

217635_PM_s_at

217635_s_at

217636_PM_at

217636_at

3638336

3638338

3638339

3638340

3638341

3638342

3638343

3638344

3638345

3638346

3638347

3638348

3638349

3638350

3638351

3638354

3638355

3638356

3638357

3638358

3638359

3638360

3638361

3638362

3638363

3638364

3638365

3638366

3638367

3638368

3638369

3638370

3638371

3638372

3638373

3638374

3638375

3638376

3638377

3638378

3638379

3638380

3638381

3638382

3638383

5428

68823_at

7991258

A_23_P3355

GE60200

GO:0000262

GO:0002020

GO:0003677

GO:0003682

GO:0003824

GO:0003887

GO:0005515

GO:0005739

GO:0005759

GO:0005760

GO:0006259

GO:0006260

GO:0006261

GO:0006264

GO:0006281

GO:0006284

GO:0006287

GO:0008310

GO:0008408

GO:0016740

GO:0016779

GO:0016787

GO:0016829

GO:0032991

GO:0034061

GO:0042645

GO:0045004

GO:0051575

GO:0071897

GO:0140097

GO:0140640

HMNXSV003033664

HMNXSV003054471

Hs.290921.0.A1_3p_at

ILMN_2101930

PH_hs_0023529

RNA147129|p0233_imsncRNA368

TC15001828.hg

U60325_at

g4505936_3p_at

g4505936_3p_s_at

g4505936_3p_x_at

Participates

as a component of

Inferred To

polg-1 [mitochondrial matrix] (Caenorhabditis elegans)

PolG1 [mitochondrial matrix] (Drosophila melanogaster)

POLG [mitochondrial matrix] (Bos taurus)

POLG [mitochondrial matrix] (Canis familiaris)

POLG [mitochondrial matrix] (Gallus gallus)

POLG [mitochondrial matrix] (Mus musculus)

POLG [mitochondrial matrix] (Rattus norvegicus)

POLG [mitochondrial matrix] (Sus scrofa)

polg [mitochondrial matrix] (Danio rerio)

polg [mitochondrial matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_002684.1, NP_001119603.1

OpenTargets

ENSG00000140521

ENSEMBL

ENSP00000399851, ENSP00000268124, ENST00000636937, ENST00000442287, ENSG00000140521, ENST00000268124, ENSP00000516154

ZINC - Substances

DPOG1_HUMAN

ZINC target

P54098

PRO

P54098

GlyGen

P54098

PDB

9IC3, 9IC1, 5C53, 8G5K, 9GGE, 8V5R, 8G5M, 8G5J, 8V5D, 9GGF, 8G5O, 8G5I, 5C51, 9GGD, 8D3R, 8G5N, 5C52, 8G5L, 3IKM, 8V54, 8V55, 9GGB, 8D42, 8D37, 8D33, 9GGC, 8T7E, 8G5P, 8UDK, 4ZTU, 4ZTZ, 8UDL

IntEnz

2.7.7.7

HPA

ENSG00000140521-POLG

GeneCards

POLG

Pharos - Targets

P54098

Orphanet

POLG

ZINC - Predictions - Purchasable

DPOG1_HUMAN

HMDB Protein

HMDBP00968

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UHN1 POLG2	1	POLG2(?-485) [mitochondrial matrix] (R-HSA-1592214)	0.946	15
UniProt:Q9BQP7 MGME1	1	MGME1 [mitochondrial matrix] (R-HSA-9915452)	0.643	3
UniProt:O95861 BPNT1	1	BPNT1 [cytosol] (R-HSA-176573)	0.527	2
UniProt:P21912 SDHB	2	SDHB [mitochondrial matrix] (R-HSA-9854983) SDHB [mitochondrial inner membrane] (R-HSA-70985)	0.527	2
UniProt:P00480 OTC	20	OTC A253P [mitochondrial matrix] (R-HSA-9957836) OTC S192R [mitochondrial matrix] (R-HSA-9958013) OTC I160T [mitochondrial matrix] (R-HSA-9957899) OTC N47I [mitochondrial matrix] (R-HSA-9957955) OTC K289D [mitochondrial matrix] (R-HSA-9957908) OTC A155E [mitochondrial matrix] (R-HSA-9957826) OTC L45P [mitochondrial matrix] (R-HSA-9956424) OTC K289N [mitochondrial matrix] (R-HSA-9957911) OTC G162E [mitochondrial matrix] (R-HSA-9957865) OTC E52G [mitochondrial matrix] (R-HSA-9957856) OTC I53S [mitochondrial matrix] (R-HSA-9957901) OTC L201P [mitochondrial matrix] (R-HSA-9957922) OTC G162R [mitochondrial matrix] (R-HSA-9957868) OTC L57Q [mitochondrial matrix] (R-HSA-9957925) OTC E52K [mitochondrial matrix] (R-HSA-9957859) OTC R320L [mitochondrial matrix] (R-HSA-9957998) OTC I160N [mitochondrial matrix] (R-HSA-9957895) OTC V311E [mitochondrial matrix] (R-HSA-9958037) OTC A140P [mitochondrial matrix] (R-HSA-9957823) OTC T125M [mitochondrial matrix] (R-HSA-9958022)	0.527	2