HIF1A,EPAS1 binding to CD274 gene

Stable Identifier
R-HSA-9909618
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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HIF1A,EPAS1 binding to CD274 gene
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HIF-1α (Hypoxia-inducible factor 1-alpha) regulates CD274 (PD-L1) transcription in response to low oxygen levels in the tumor microenvironment. Under hypoxic conditions, HIF-1α stabilizes and translocates to the nucleus, where it binds to hypoxia-responsive elements (HREs) in the PD-L1 promoter region. This binding recruits co-activators and transcriptional machinery, increasing PD-L1 transcription. Elevated PD-L1 expression helps tumor cells evade immune detection by inhibiting T cell activity. HIF-1α's role in upregulating PD-L1 under hypoxia highlights its importance in cancer progression and as a potential target for therapies aimed at reducing immune escape in tumors. (Ding et al., 2021, Noman et al.,2014, Xanthopoulou et al., 2023)
Literature References
PubMed ID Title Journal Year
34118979 The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia

Ding, XC, Wang, LL, Zhang, XD, Xu, JL, Li, PF, Liang, H, Zhang, XB, Xie, L, Zhou, ZH, Yang, J, Weichselbaum, RR, Yu, JM, Hu, M

J Hematol Oncol 2021
24778419 PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

Noman, MZ, Desantis, G, Janji, B, Hasmim, M, Karray, S, Dessen, P, Bronte, V, Chouaib, S

J Exp Med 2014
37067635 HIF1α-dependent and independent pathways regulate the expression of PD-L1 in prostate cancer

Xanthopoulou, ET, Kakouratos, C, Nanos, C, Gkegka, AG, Kalaitzis, C, Giatromanolaki, A, Koukourakis, MI

Med Oncol 2023
Participants
Input
Output
Participates
as an event of
Authored
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Tiwari, K  (2024-11-05)
Reviewed
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Created
Tiwari, K  (2024-05-14)
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