Formation of CRY:PER:Kinase complex

Stable Identifier
R-HSA-9909392
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Formation of CRY:PER:Kinase complex
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Cryptochrome proteins (CRY1, CRY2), Period proteins (PER1, PER2, PER3), and a kinase, CSNK1D and/or CSNK1E (CKIepsilon or CKIdelta), form a complex in the cytosol (Keesler et al. 2000, Camacho et al. 2001, and inferred from mouse homologs). CRY1, CRY2, PER1, PER2, PER3 and kinases assemble into a single large complex which enters the nucleus and binds BMAL1:CLOCK heterodimers (inferred from mouse homologs). CRY proteins contain nuclear localization signals, bind PER proteins (inferred from mouse homologs), and cause translocation of the complex into the nucleus (inferred from mouse homologs). Phosphorylation of PER2 on serine-396 (serine-394 of mouse Per2) by CDK5 during the day increases the interaction between PER2 and CRY1 (inferred from mouse homologs in Brenna et al. 2019). CSNK1E binds and phosphorylates PER2 (inferred from mouse homologs). The association between CSNK1E and PER1 appears to mask a nuclear localization signal in PER1 and makes nuclear translocation of PER1 dependent on phosphorylation of PER1 (inferred from mouse homologs). PER3 does not directly interact with CSNK1E (inferred from mouse homologs). CSNK1E also phosphorylates CRY proteins and the phosphorylation is dependent on the interaction between CRY proteins and PER proteins, which may act as scaffolds (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
10790862 Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon

Keesler, GA, Camacho, F, Guo, Y, Virshup, D, Mondadori, C, Yao, Z

Neuroreport 2000
11165242 Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2

Camacho, F, Cilio, M, Guo, Y, Virshup, DM, Patel, K, Khorkova, O, Styren, S, Morse, B, Yao, Z, Keesler, GA

FEBS Lett 2001
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Input
Output
Participates
as an event of
Inferred From
Formation of Cry:Per:Kinase complex (Mus musculus)
Authored
May, B  (2024-05-13)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-05-13)
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