Formation of the PA28gamma-20S proteasome

Stable Identifier
R-HSA-9908721
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
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Formation of the PA28gamma-20S proteasome
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Based on a structural study of proteasomes isolated from human embryonic kidney cell line HEK293T, the PA28gamma homoheptamer, composed of PSME3 (PA28gamma) subunit, forms a complex with the 20S core particle (20S CP), resulting in the P28gamma-20S proteasome (Zhao et al. 2022). The function of the PA28gamma-20S proteasome is unknown, but may play a role in the quick removal of damaged and unfolded proteins from the cell in response to oxidative stress (Zhao et al. 2022).
Literature References
PubMed ID Title Journal Year
35858375 Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins

Zhao, J, Makhija, S, Zhou, C, Zhang, H, Wang, Y, Muralidharan, M, Huang, B, Cheng, Y

Proc Natl Acad Sci U S A 2022
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Orthologous Events
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Authored
Orlic-Milacic, M  (2024-04-22)
Created
Orlic-Milacic, M  (2024-04-22)
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