Reactome | PSMG3 binds PSMG4

PSMG3 binds PSMG4

Stable Identifier

R-HSA-9908041

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

3/5

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Proteasome chaperone proteins PSMG3 (also known as PAC3, ortholog of yeast Pba3) and PSMG4 (also known as PAC4, ortholog of yeast Pba4) form an evolutionarily conserved heterodimer initially detected in yeast (Yashiroda et al. 2008), but also confirmed and structurally characterized using human proteins (Kurimoto et al. 2017, Satoh et al. 2019). For review, please refer to Tomko and Hochstrasser 2013.

Literature References

PubMed ID	Title	Journal	Year
28263418	Crystal structure of human proteasome assembly chaperone PAC4 involved in proteasome formation Kurimoto, E, Satoh, T, Ito, Y, Ishihara, E, Okamoto, K, Yagi-Utsumi, M, Tanaka, K, Kato, K	Protein Sci	2017
31067643	Molecular and Structural Basis of the Proteasome α Subunit Assembly Mechanism Mediated by the Proteasome-Assembling Chaperone PAC3-PAC4 Heterodimer Satoh, T, Yagi-Utsumi, M, Okamoto, K, Kurimoto, E, Tanaka, K, Kato, K	Int J Mol Sci	2019