Formation of the 19S regulatory particle precursor

Stable Identifier
R-HSA-9908026
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
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Formation of the 19S regulatory particle precursor
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Precursor of the proteasome 19S regulatory particle (19S RP) base associates with the lid to form the 19S RP precursor. In yeast, a highly evolutionarily conserved C-terminal tail of Rpn12 (ortholog of human PSMD8) and the protein Rpn10 (ortholog of human PSMD4) play crucial roles in lid-base association (reviewed in Tomko and Hochstrasser 2013). In human proteasome, however, no direct interaction between PSMD4 (Rpn10) and PSMD8 (Rpn12) was detected and PSMD4 (Rpn10) was instead shown to bind to a base protein PSMD1 (Rpn2) and a lid protein PSMD14 (Rpn11) (Hendil et al. 2009). A complex of nascent human PSMD1 (Rpn2), PSMD4 (Rpn10), PSMD14 (Rpn11), ADRM1 (Rpn13), and TXNL1 may exist attached to the 20S core particle (20S CP) before the formation of the 19S RP (Hendil et al. 2009). In the study of human 19S RP assembly, it was shown that PSMD4 (Rpn10) levels were decreased in the absence of either the base subunits or the lid subunit PSMD3 (Rpn3), suggesting that PSMD4 (Rpn10) is stabilized only when both the base and the lid are integrated into 19S RP (Kaneko et al. 2009).
Literature References
PubMed ID Title Journal Year
19781552 The 20S proteasome as an assembly platform for the 19S regulatory complex

Hendil, KB, Kriegenburg, F, Tanaka, K, Murata, S, Lauridsen, AM, Johnsen, AH, Hartmann-Petersen, R

J Mol Biol 2009
19490896 Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones

Kaneko, T, Hamazaki, J, Iemura, S, Sasaki, K, Furuyama, K, Natsume, T, Tanaka, K, Murata, S

Cell 2009
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Orthologous Events
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Authored
Orlic-Milacic, M  (2024-04-22)
Created
Orlic-Milacic, M  (2024-04-18)
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