Formation of the complex of PSMD3, PSMD6, and SEM1

Stable Identifier
R-HSA-9908007
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
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Formation of the complex of PSMD3, PSMD6, and SEM1
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Components of the proteasome 19S regulatory particle (19S RP) lid, PSMD3 (ortholog of yeast Rpn3), PSMD6 (ortholog of yeast Rpn7) and SEM1 (ortholog of yeast Sem1, also known as Rpn15) bind to form the complex known as the Lid particle 3 (LP3) (reviewed in Tomko and Hochstrasser 2013). The existence of the lid subcomplex composed of PSMD3 (Rpn3), PSMD6 (Rpn7), and SEM1 (Rpn15) was confirmed in human embryonic kidney cell line HEK293T (Bai et al. 2019). SEM1 interacts directly with PSMD3 and is required for binding of PSMD3 to PSMD6 (Bai et al. 2019).
Literature References
PubMed ID Title Journal Year
31159305 In-depth Analysis of the Lid Subunits Assembly Mechanism in Mammals

Zhao, X, Murata, S, Hirano, Y, Sahara, K, Bai, M, Ohte, Y, Yashiroda, H, Kaneko, T

Biomolecules 2019
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Authored
Orlic-Milacic, M  (2024-04-22)
Created
Orlic-Milacic, M  (2024-04-18)
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