Reactome | PSMC2 binds PSMC1

PSMC2 binds PSMC1

Stable Identifier

R-HSA-9907954

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

3/5

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Subunits of the base of the 19S regulatory particle (19S RP) of the 26S proteasome, PSMC2 and PSMC1, which are orthologs of yeast Rpt1 and Rpt2, respectively, form a dimer (reviewed in Tomko and Hochstrasser 2013). Direct association of endogenous human PSMC1 (Rpt2) and PSMC2 (Rpt1) was demonstrated in the human embryonic kidney cell line HEK293T, and confirmed in vitro by using recombinant human proteins (Kaneko et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19490896	Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones Kaneko, T, Hamazaki, J, Iemura, S, Sasaki, K, Furuyama, K, Natsume, T, Tanaka, K, Murata, S	Cell	2009