Reactome | PSMC4 binds PSMC5

PSMC4 binds PSMC5

Stable Identifier

R-HSA-9907951

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

3/5

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Subunits of the base of the proteasome 19S regulatory particle (19S RP), PSMC4 and PSMC5, which are orthologues of yeast Rpt3 and Rpt6, respectively, form an evolutionarily conserved dimer (reviewed in Tomko and Hochstrasser 2013). Formation of a heterodimer between nascent human PSMC4 (Rpt3) and PSMC5 (Rpt5) before their incorporation into the 19S RP was shown in human cervical carcinoma cell line HeLa (Hendil et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19781552	The 20S proteasome as an assembly platform for the 19S regulatory complex Hendil, KB, Kriegenburg, F, Tanaka, K, Murata, S, Lauridsen, AM, Johnsen, AH, Hartmann-Petersen, R	J Mol Biol	2009