Reactome | Fromation of the preholoimmunoproteasome

Fromation of the preholoimmunoproteasome

Stable Identifier

R-HSA-9907941

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

3/5

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Fromation of the preholoimmunoproteasome

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The immunoproteasome 20S core particle (20S iCP), like the canonical 20S CP, consists of four axially stacked heteroheptameric rings - two inner rings and two outer rings (Santos et al. 2017: cryogenic electron microscopy structure of human 20S iCP; reviewed in Tomko and Hochstrasser 2013). In the 20S iCP, the inner ring subunits with proteolytic activity, PSMB6 (beta-1), PSMB7 (beta-2), and PSMB5 (beta-5), are substituted with PSMB9 (beta-1i), PSMB10 (beta-2i), and PSMB8 (beta-5i), respectively (Santos et al. 2017: cryogenic electron microscopy structure of human 20S iCP; reviewed in Tomko and Hochstrasser 2013). The immunoproteasome generates substrate cleavage patterns that enhance loading of peptides onto the class I major histocompatibility complex for immune presentation to killer T cells (reviewed in Tomko and Hochstrasser 2013).

Literature References

PubMed ID	Title	Journal	Year
29167449	Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes Santos, RLA, Bai, L, Singh, PK, Murakami, N, Fan, H, Zhan, W, Zhu, Y, Jiang, X, Zhang, K, Assker, JP, Nathan, CF, Li, H, Azzi, J, Lin, G	Nat Commun	2017