Reactome | Formation of the preholothymoproteasome

Formation of the preholothymoproteasome

Stable Identifier

R-HSA-9907940

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

3/5

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The 20S thymoproteasome core particle (20S tCP) can be isolated from human immune system-derived cell lines already expressing PSMB9 (beta-1i) and PSMB10 (beta-2i), which replace the constitutive PSMB6 (beta-1) and PSBM7 (beta-2), respectively, that were engineered to overexpress PSMB11 (beta-5t) (Kuckelkorn et al. 2019).

Literature References

PubMed ID	Title	Journal	Year
30914481	Proteolytic dynamics of human 20S thymoproteasome Niewienda, A, Kuckelkorn, U, Kilian, C, Stumpf, MPH, Janek, K, Stübler, S, Mishto, M, Textoris-Taube, K, Henklein, P, Liepe, J	J Biol Chem	2019