Reactome | Formation of the preholothymoproteasome

Formation of the preholothymoproteasome

Stable Identifier

R-HSA-9907940

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

3/5

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The 20S thymoproteasome core particle (20S tCP) can be isolated from human immune system-derived cell lines already expressing PSMB9 (beta-1i) and PSMB10 (beta-2i), which replace the constitutive PSMB6 (beta-1) and PSBM7 (beta-2), respectively, that were engineered to overexpress PSMB11 (beta-5t) (Kuckelkorn et al. 2019).

Literature References

PubMed ID	Title	Journal	Year
30914481	Proteolytic dynamics of human 20S thymoproteasome Kuckelkorn, U, Stübler, S, Textoris-Taube, K, Kilian, C, Niewienda, A, Henklein, P, Janek, K, Stumpf, MPH, Mishto, M, Liepe, J	J Biol Chem	2019