Pannexin1 (PANX1) channel in a complex with P2RX7 transports ATP from the cytosol to the extracellular region

Stable Identifier
R-HSA-9905999
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
ReviewStatus
5/5
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Pannexin1 (PANX1) channel in a complex with P2RX7 transports ATP from the cytosol to the extracellular region
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The homoheptameric PANX1 (Pannexin-1) channel (Ruan et al. 2020, Zhang et al. 2021, Kuzuya et al. 2022) transports ATP from the cytosol to the extracellular region in response to mechanical stimuli such as membrane stretching (Bao et al. 2004, Wang et al. 2016). In osteocytes, PANX1 channels are activated by elevated cytosolic calcium (Locovei et al. 2006) and directly interact with the ATP-gated cation channel P2RX7, which imports calcium (Locovei et al. 2006), therefore P2RX7 and PANX1 may constitute a positive feedback loop.
Literature References
PubMed ID Title Journal Year
16364313 Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium

Locovei, S, Wang, J, Dahl, G

FEBS Lett 2006
15304325 Pannexin membrane channels are mechanosensitive conduits for ATP

Bao, L, Locovei, S, Dahl, G

FEBS Lett 2004
27797339 Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

Wang, S, Chennupati, R, Kaur, H, Iring, A, Wettschureck, N, Offermanns, S

J Clin Invest 2016
Participants
Input
Output
Participates
as an event of
Catalyst Activity

channel activity of P2RX7:PANX1,ATP:P2RX7:PANX1 [plasma membrane]

Physical Entity
P2RX7:PANX1,ATP:P2RX7:PANX1 [plasma membrane] (Homo sapiens)
Activity
channel activity (GO:0015267)
This event is regulated
Positively by
Regulator
Ca2+ [cytosol]
Inferred From
Pannexin-1 (Panx1) channel transports ATP from the cytosol to the extracellular region (Mus musculus)
Cross References
RHEA
Authored
May, B  (2024-03-29)
Reviewed
Farach-Carson, MC  (2024-10-27)
Wu, D  (2024-10-27)
Created
May, B  (2024-03-29)
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