Reactome | HCCS inserts heme into cytochrome c

HCCS inserts heme into cytochrome c

Stable Identifier

R-HSA-9866217

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

ReviewStatus

5/5

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Holocytochrome c-type synthase (HCCS, aka cytochrome c-type heme lyase, CCHL) catalyzes the insertion and covalent binding of heme to apo-cytochrome c (CYCS), an essential electron carrier in mitochondria (Wimplinger et al., 2006; San Francisco et al., 2013).

Literature References

PubMed ID	Title	Journal	Year
23150584	Human mitochondrial holocytochrome c synthase's heme binding, maturation determinants, and complex formation with cytochrome c San Francisco, B, Bretsnyder, EC, Kranz, RG	Proc Natl Acad Sci U S A	2013
17033964	Mutations of the mitochondrial holocytochrome c-type synthase in X-linked dominant microphthalmia with linear skin defects syndrome Wimplinger, I, Morleo, M, Rosenberger, G, Iaconis, D, Orth, U, Meinecke, P, Lerer, I, Ballabio, A, Gal, A, Franco, B, Kutsche, K	Am J Hum Genet	2006