Reactome | Late core complex dimer binds UQCR10, UQCR11, UQCRFS1.

Late core complex dimer binds UQCR10, UQCR11, UQCRFS1.

Stable Identifier

R-HSA-9866164

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Late core complex dimer binds UQCR10, UQCR11, UQCRFS1.

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of UQCR10, UQCR11, and UQCRFS1 to the late core complex dimer is the last step of Complex III assembly (reviewed in Ndi et al., 2018; Zara et al., 2022). This assembly step is inferred from its equivalent in yeast. The process requires the presence of the BCS1L:LETM1 complex (Cruciat et al., 1999; Tamai et al., 2008; Wagener et al., 2011; Fernandez-Vizarra et al., 2007).

Literature References

PubMed ID	Title	Journal	Year
36142449	Assembly of the Multi-Subunit Cytochrome bc₁ Complex in the Yeast Saccharomyces cerevisiae Zara, V, Ferramosca, A, De Blasi, G	Int J Mol Sci	2022
28844695	Architecture of Human Mitochondrial Respiratory Megacomplex I₂III₂IV₂ Guo, R, Zong, S, Yang, M, Gu, J, Wu, M	Cell	2017
29733856	Biogenesis of the bc₁ Complex of the Mitochondrial Respiratory Chain Marin-Buera, L, Ott, M, Salvatori, R, Ndi, M, Singh, AP	J Mol Biol	2018