Reactome | MT-CYB is translated

MT-CYB is translated

Stable Identifier

R-HSA-9865893

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial matrix

ReviewStatus

5/5

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Human cytochrome b (MT-CYB) mRNA gets translated by mitoribosomes. The chaperone complex UQCC1:UQCC2:UQCC5:UQCC6 co-translationally binds to CYTB and helps with folding inside the mitochondrial membrane. The resulting protein-chaperone complex is called intermediate 0 (Tucker et al., 2013; Dennerlein et al., 2021; reviewed in Ndi et al., 2018; Zara et al., 2022). This assembly step is inferred from its equivalent in yeast.

Literature References

PubMed ID	Title	Journal	Year
34969438	Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors Dennerlein, S, Poerschke, S, Oeljeklaus, S, Wang, C, Richter-Dennerlein, R, Sattmann, J, Bauermeister, D, Hanitsch, E, Stoldt, S, Langer, T, Jakobs, S, Warscheid, B, Rehling, P	Elife	2021
36142449	Assembly of the Multi-Subunit Cytochrome bc₁ Complex in the Yeast Saccharomyces cerevisiae Zara, V, De Blasi, G, Ferramosca, A	Int J Mol Sci	2022
29733856	Biogenesis of the bc₁ Complex of the Mitochondrial Respiratory Chain Ndi, M, Marin-Buera, L, Salvatori, R, Singh, AP, Ott, M	J Mol Biol	2018
24385928	Mutations in the UQCC1-interacting protein, UQCC2, cause human complex III deficiency associated with perturbed cytochrome b protein expression Tucker, EJ, Wanschers, BF, Szklarczyk, R, Mountford, HS, Wijeyeratne, XW, van den Brand, MA, Leenders, AM, Rodenburg, RJ, Reljic, B, Compton, AG, Frazier, AE, Bruno, DL, Christodoulou, J, Endo, H, Ryan, MT, Nijtmans, LG, Huynen, MA, Thorburn, DR	PLoS Genet	2013