p-S446-IRF5 dimer translocates to the nucleus

Stable Identifier
R-HSA-9860278
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-S446-IRF5 dimer translocates to the nucleus
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Upon stimulation, the transcription factor IRF5 is activated by phosphorylation at Ser446 (refers to the UniProtKB canonical sequence) leading to homodimerization and translocation of the p-S446-IRF5 dimer to the nucleus.
Literature References
PubMed ID Title Journal Year
18836453 Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5

Chen, W, Lam, SS, Srinath, H, Jiang, Z, Correia, JJ, Schiffer, CA, Fitzgerald, KA, Lin, K, Royer, WE

Nat Struct Mol Biol 2008
Participants
Input
Output
Participates
as an event of
Orthologous Events
p-S446-IRF5 dimer translocates to the nucleus (Bos taurus)
p-S446-IRF5 dimer translocates to the nucleus (Canis familiaris)
p-S446-IRF5 dimer translocates to the nucleus (Danio rerio)
p-S446-IRF5 dimer translocates to the nucleus (Gallus gallus)
p-S446-IRF5 dimer translocates to the nucleus (Mus musculus)
p-S446-IRF5 dimer translocates to the nucleus (Rattus norvegicus)
p-S446-IRF5 dimer translocates to the nucleus (Sus scrofa)
Authored
Shamovsky, V  (2024-02-06)
Reviewed
Löw, C  (2024-05-02)
Heinz, LX  (2024-05-13)
Toyama-Sorimachi, N  (2024-11-15)
Created
Shamovsky, V  (2024-02-01)
Cite Us!