Reactome | Dimerization of p-S446-IRF5

Dimerization of p-S446-IRF5

Stable Identifier

R-HSA-9860273

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - SLC15A4:TASL-dependent IRF5 activation (Homo sapiens)
        
        Dimerization of p-S446-IRF5 (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - SLC15A4:TASL-dependent IRF5 activation (Homo sapiens)
        
        Dimerization of p-S446-IRF5 (Homo sapiens)

General

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Phosphorylated IRF5 (p-S446-IRF5, refers to the UniProtKB canonical sequence) forms homodimers and translocates to the nucleus to stimulate production of type I interferons.

Literature References

PubMed ID	Title	Journal	Year
25326420	IKKβ is an IRF5 kinase that instigates inflammation Ren, J, Chen, X, Chen, ZJ	Proc Natl Acad Sci U S A	2014
18836453	Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5 Chen, W, Lam, SS, Srinath, H, Jiang, Z, Correia, JJ, Schiffer, CA, Fitzgerald, KA, Lin, K, Royer, WE	Nat Struct Mol Biol	2008