Expression of the LIPE gene, encoding a hormone sensitive lipase primarily responsible for hydrolysis of stored triglycerides to free fatty acids (reviewed in Althaher 2022), is positively regulated in fat tissue by the PPARG:RXRA heterodimer and KMT2C (MLL3)/KMT2D (MLL4) histone methyltransferase complexes. In differentiating primary human adipocytes, LIPE mRNA levels are reduced upon antisense-mediated knockdown of PPARG mRNA (Perera et al. 2006, Supplementary materials Table 2). Expression of the Lipe gene is severely reduced in differentiating mouse brown preadipocytes expressing histone H3.3 K4M mutant or Kmt2c (Mll3) and Kmt2d (Mll4) with deleted SET domains (Jang et al. 2019: RNA-seq, supplementary information).