p-S-ITGA5:ITGB1 binds p-S373-GJA1

Stable Identifier
R-HSA-9857703
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-S-Integrin alpha5:Integrin beta 1 binds p-S373-Connexin-43
ReviewStatus
5/5
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p-S-ITGA5:ITGB1 binds p-S373-GJA1
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Phosphorylation of integrin alpha5 (ITGA5) and Connexin 43 (Cx43, GJA1) by AKT1 enhances their mutual association and the enhances the opening of the GJA1 hemichannel (inferred from mouse homologs). Mechanical stimulus activates the fibronectin-binding activity of integrin alpha5:integrin beta1 (ITGA5:ITGB1), though interaction of ITGA5:ITGB1 with extracellular fibronectin is not required for opening of GJA1 hemichannels (inferred from mouse homologs).
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Output
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as an event of
Inferred From
p-S-Itga5:Itgb1 binds p-S373-Gja1 (Mus musculus)
Authored
May, B  (2024-01-05)
Reviewed
Farach-Carson, MC  (2024-10-27)
Wu, D  (2024-10-27)
Created
May, B  (2024-01-08)
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