ATF5 and HSF1 trimer activate expression of HSPD1

Stable Identifier
R-HSA-9856666
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, mitochondrial matrix
ReviewStatus
3/5
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ATF5 and HSF1 trimer activate expression of HSPD1
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During the mitochondrial response to unfolded protein (mtUPR), a reduction of mitochondrial protein import causes ATF5 to accumulate in the nucleus and activate expression of the mitochondrial chaperone HSPD1 (HSP60) (Fiorese et al. 2016). Trimeric Heat shock factor protein 1 (HSF1) phosphorylated on serine-326 is also required for expression of HSPD1 during the mtUPR Sutndy et al. 2023, inferred from mouse homologs in Katiyar et al. 2020).
Literature References
PubMed ID Title Journal Year
37286597 A cytosolic surveillance mechanism activates the mitochondrial UPR

Sutandy, FXR, Gößner, I, Tascher, G, Münch, C

Nature 2023
27426517 The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

Fiorese, CJ, Schulz, AM, Lin, YF, Rosin, N, Pellegrino, MW, Haynes, CM

Curr Biol 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
ATF5:HSF1 trimer:HSPD1 gene:HSPE1 gene [nucleoplasm] (Homo sapiens)
Active Unit
ATF5 [nucleoplasm]
p-S326-hC36,103-HSF1 [nucleoplasm]
Authored
May, B  (2023-12-20)
Created
May, B  (2023-12-21)
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