MLXIPL:MLX binds ACACB gene promoter

Stable Identifier
R-HSA-9856548
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MLXIPL:MLX binds ACACB gene promoter
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As part of the physiological response to high dietary carbohydrate intake, two copies of the MLXIPL:MLX (ChREBP:MLX) complex bind to the carbohydrate response element (ChoRE) in the promoter of the ACACB (Acetyl-CoA carboxylase 2) gene (Ma et al. 2005, 2006, 2007; Stoeckman et al. 2004).
Literature References
PubMed ID Title Journal Year
17148476 A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription

Sham, YY, Towle, HC, Ma, L, Walters, KJ

Nucleic Acids Res. 2007
16885160 ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver

Towle, HC, Ma, L, Robinson, LN

J. Biol. Chem. 2006
15664996 Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.

Ma, L, Tsatsos, NG, Towle, HC

J Biol Chem 2005
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Catalyst Activity

DNA-binding transcription activator activity, RNA polymerase II-specific of MLXIPL:MLX [nucleoplasm]

Physical Entity
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
Activity
DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)
Authored
D'Eustachio, P  (2023-12-20)
Reviewed
Hill, DP  (2024-02-12)
Created
D'Eustachio, P  (2023-12-19)
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