Reactome | ROS,RNS oxidize ACO2:4Fe-4S

ROS,RNS oxidize ACO2:4Fe-4S

Stable Identifier

R-HSA-9854368

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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Mitochondrial aconitase (ACO2) acts as a redox sensor in the TCA cycle. The binding of reactive oxygen and nitrogen species (ROS, RNS) leads to the oxidation of ACO2's 4Fe-4S cluster with subsequent loss of a Fe2+ ion (Beinert et al., 1996). In particular, ACO2 is extremely sensitive to inactivation by the peroxide radical (Gardner & Fridovich, 1992). The enzyme is also an essential target of nitroxidative species (Tórtora et al., 2007).

Literature References

PubMed ID	Title	Journal	Year
1315737	Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical Gardner, PR, Fridovich, I	J Biol Chem	1992
11848830	Aconitase as Iron-Sulfur Protein, Enzyme, and Iron-Regulatory Protein Beinert, H, Kennedy, MC, Stout, CD	Chem Rev	1996
17349934	Mitochondrial aconitase reaction with nitric oxide, S-nitrosoglutathione, and peroxynitrite: mechanisms and relative contributions to aconitase inactivation Tórtora, V, Quijano, C, Freeman, B, Radi, R, Castro, L	Free Radic Biol Med	2007