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N6,N6,N6-trimethyl-K395-CS [mitochondrial matrix]
Stable Identifier
R-HSA-9854321
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
citrate synthase, Citrate synthase, mitochondrial precursor
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
CS acetylates OA to citrate (Homo sapiens)
N6,N6,N6-trimethyl-K395-CS dimer [mitochondrial matrix] (Homo sapiens)
N6,N6,N6-trimethyl-K395-CS [mitochondrial matrix] (Homo sapiens)
Maturation of TCA enzymes and regulation of TCA cycle (Homo sapiens)
CSKMT methylates Citrate Synthase (Homo sapiens)
Methylated(n+1) CS dimer [mitochondrial matrix] (Homo sapiens)
N6,N6,N6-trimethyl-K395-CS dimer [mitochondrial matrix] (Homo sapiens)
N6,N6,N6-trimethyl-K395-CS [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75390 CS
Gene Names
CS
Chain
transit peptide:1-27, chain:28-466
Reference Genes
BioGPS Gene:1431 CS
COSMIC (genes):CS CS
CTD Gene:1431 CS
dbSNP Gene:1431 CS
ENSEMBL:ENSG00000062485 CS
HGNC:2422 CS
KEGG:hsa:1431 CS
Monarch:1431 CS
NCBI Gene:1431 CS
OMIM:118950 CS
UCSC:O75390 CS
Reference Transcript
RefSeq:NM_004077.2 CS
Other Identifiers
11748037_s_at
11748038_s_at
11760113_at
1431
16765998
16766001
17121958
208660_PM_at
208660_at
3457613
3457615
3457616
3457617
3457618
3457619
3457620
3457621
3457622
3457623
3457624
3457625
3457626
3457627
3457628
3457629
3457630
3457631
3457632
3457633
3457634
3457635
3457636
3457637
3457638
3457639
3457640
3457641
3457645
3457646
3457648
3457652
3457653
3457654
3457655
3457656
3824754
3824755
3824756
3824758
3824759
3824764
3824768
41314_at
60743_at
7964064
A_23_P47818
A_33_P3215078
GE61606
GO:0003723
GO:0003824
GO:0004108
GO:0005634
GO:0005739
GO:0005759
GO:0005975
GO:0006099
GO:0006101
GO:0016020
GO:0016740
GO:0036440
GO:0042802
GO:0043226
GO:0046912
GO:0070062
HMNXSV003030319
HMNXSV003037834
ILMN_1706057
ILMN_1709775
ILMN_2396410
TC12003213.hg
g12652712_3p_at
Participates
as a component of
N6,N6,N6-trimethyl-K395-CS dimer [mitochondrial matrix] (Homo sapiens)
Other forms of this molecule
CS(1-466) [mitochondrial intermembrane space]
CS(1-466) [cytosol]
CS [mitochondrial matrix]
N6,N6-dimethyl-K395-CS [mitochondrial matrix]
N6-methyl-K395-CS [mitochondrial matrix]
Inferred To
cs [mitochondrial matrix]
(Dictyostelium discoideum)
cts-1 [mitochondrial matrix]
(Caenorhabditis elegans)
Cs1 [mitochondrial matrix]
(Drosophila melanogaster)
N6,N6,N6-trimethyl-K395-CS [mitochondrial matrix]
(Bos taurus)
N6,N6,N6-trimethyl-K395-CS [mitochondrial matrix]
(Danio rerio)
N6,N6,N6-trimethyl-K395-CS [mitochondrial matrix]
(Gallus gallus)
N6,N6,N6-trimethyl-K395-CS [mitochondrial matrix]
(Mus musculus)
N6,N6,N6-trimethyl-K395-CS [mitochondrial matrix]
(Plasmodium falciparum)
N6,N6,N6-trimethyl-K395-CS [mitochondrial matrix]
(Rattus norvegicus)
N6,N6,N6-trimethyl-K395-CS [mitochondrial matrix]
(Sus scrofa)
N6,N6,N6-trimethyl-K395-CS [mitochondrial matrix]
(Xenopus tropicalis)
CIT1 [mitochondrial matrix]
(Saccharomyces cerevisiae)
CS [mitochondrial matrix]
(Canis familiaris)
cit1 [mitochondrial matrix]
(Schizosaccharomyces pombe)
Modified Residues
Name
N6,N6,N6-trimethyl-L-lysine at 395
Coordinate
395
PsiMod Name
N6,N6,N6-trimethyl-L-lysine [MOD:00083]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.
Cross References
RefSeq
NP_004068.2
ENSEMBL
ENST00000351328
,
ENSP00000342056
OpenTargets
ENSG00000062485
IntEnz
2.3.3.1
HPA
ENSG00000062485-CS
PRO
O75390
Pharos - Targets
O75390
GlyGen
O75390
HMDB Protein
HMDBP00043
PDB
5UZQ
,
5UZR
,
5UZP
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