ACSS3 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex

Stable Identifier
R-HSA-9854128
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, mitochondrial matrix
ReviewStatus
3/5
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ACSS3 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex
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Based on a mouse model of hepatic steatosis, expression of the ACSS3 gene, encoding Acyl-CoA synthetase short-chain family member 3 that localizes to the mitochondrial matrix, is directly stimulated by PPARG2 and the MLL4 complex (Kim et al. 2016).
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Input
Output
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as an event of
This event is regulated
Positively by
Regulator
Activated p-Y78,Y102-PPARG2:RXRA:ACSS3 gene:H3K4me1-nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] (Homo sapiens)
Inferred From
Acss3 gene expression is stimulated by Pparg2:Rxra and Mll4,(Mll3) complex (Mus musculus)
Authored
Orlic-Milacic, M  (2023-11-22)
Created
Orlic-Milacic, M  (2023-11-22)
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