PLK1 phosphorylates FIRRM at S43

Stable Identifier
R-HSA-9851972
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PLK1 phosphorylates FIRRM (also known as Apolo1 or FLIP) at serine residue S43, which increases the binding affinity of FIRRM for PLK1 (Xu et al. 2021).
Literature References
PubMed ID Title Journal Year
34260926 Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation

Sun, B, Tian, R, Poser, I, Garba, F, Li, L, Liu, X, Green, H, Chu, L, Ge, Y, Dou, Z, Lu, J, Pan, W, Yuan, X, Liu, D, Wang, D, Mullen, M, Duan, W, Duan, H, Ali, M, Hyman, A, Yao, X, Xu, L

Cell Rep 2021
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of FIRRM:p-T210-PLK1 [cytosol]

Orthologous Events
Authored
Reviewed
Created
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