Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin

Stable Identifier
R-HSA-984648
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin
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Cytokinesis requires the central spindle, which forms during anaphase by the bundling of antiparallel nonkinetochore microtubules. Microtubule bundling and completion of cytokinesis require MKLP1, a kinesin-6 family member, and RACGAP1 (MgcRacGap), which contains a RhoGAP domain. These form a heterotetrameric complex known as centralspindlin. Centralspindlin, but not its individual components, strongly promotes microtubule bundling in vitro.

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Orthologous Events
Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Caenorhabditis elegans)
Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Canis familiaris)
Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Danio rerio)
Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Drosophila melanogaster)
Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Gallus gallus)
Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Mus musculus)
Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Rattus norvegicus)
Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Sus scrofa)
Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Xenopus tropicalis)
Authored
Akkerman, JW  (2010-10-29)
Reviewed
Ouwehand, WH  (2010-11-12)
Created
Jupe, S  (2010-11-02)
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